Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
---|---|---|---|---|---|---|---|---|---|---|---|
|
0.080 | Biomarker | disease | BEFREE | Thus, recently we synthesized novel paullone-like scaffold, 5H-benzo [2, 3][1,4]oxazepino[5,6-b]indoles, where compounds 13a and 14a attenuated the growth of liver cancer specific Hep-G2 cells in vitro and formed stable binding complex with IL-6. | 29486150 | 2018 | ||||
|
0.080 | Biomarker | disease | BEFREE | It has been reported that long noncoding RNA (lncRNA) DILC inhibited IL-6 to regulate liver cancer stem cells. | 31069838 | 2019 | ||||
|
0.080 | Biomarker | disease | BEFREE | IL-6 produced by human fibroblast-like synoviocytes (HFLS) promotes rheumatoid arthritis (RA), while lncRNA DILC regulates liver cancer stem cells by inhibiting IL-6. | 30944206 | 2019 | ||||
|
0.080 | Biomarker | disease | BEFREE | Constitutive activation of Signal Transducer and Activator of Transcription 3 (STAT3) induced by IL-6 is frequently detected in liver cancer and has emerged as a viable molecular target for liver cancer treatment. | 28430601 | 2017 | ||||
|
0.080 | GeneticVariation | disease | BEFREE | Long-term genetically-reduced circulating IL-6 might be causally associated with a lower risk of liver cancer. | 26096712 | 2015 | ||||
|
0.080 | Biomarker | disease | BEFREE | These results suggest that long-term rapamycin treatment, which also increases IL-6 production in humans, is unsuitable for prevention or treatment of obesity-promoted liver cancer. | 24910242 | 2014 | ||||
|
0.080 | Biomarker | disease | BEFREE | Application of the JAK2 inhibitor AZD1480 and IL6 neutralizing antibody showed the CD90 and SHH/Gli-regulated liver cancer stem cell functions were mediated by the IL6/JAK2/STAT3 pathway. | 29722127 | 2018 | ||||
|
0.080 | Biomarker | disease | BEFREE | Interactions between interleukin-6 and myeloid-derived suppressor cells drive the chemoresistant phenotype of hepatocellular cancer. | 28109867 | 2017 |